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Analysis was done using Stata 14 version software. The median tumour size was 2. The majority of the patients had invasive ductal cancer Demographic and clinicopathological characteristics are summarised in Table 1. Therefore, we have analysed the data in two time frames: —7 versus —20 Table 3. With the introduction of ICG, the dual dye method was used in The SLNB positivity rate was Out of 1, patients in whom MB was injected, 1 had skin necrosis, and 16 patients had bluish discolouration of the skin 1 week after surgery.

The lymphedema rate was 5. The side effects of MB dye injections, like skin necrosis and hypersensitivity reaction, were minimal in our series. Although median follow up time was 27 months in our study, ARR of 0. We started our SLNB program with radioactive dye in and have faced the challenge of radioactive dye use in developing countries, as reported before [ 11 ]. In comparison, MB dye has been reported safer with regards to anaphylactic reaction [ 10 ].

In our large series, we did not notice a single hypersensitivity reaction to MB dye. Although MB dye is safer and not associated with life-threatening hypersensitivity reactions, some authors have reported skin staining and necrosis of the local injection area [ 19 , 20 ]. In our series, 1 patient had skin necrosis which was managed by debridement and secondary skin suturing, and 16 patients had bluish stating of the injection site beyond 1-week post-surgery.

We found a significant lower lymphedema rate of 0. In summary, the SLNB procedure was done by different methods using blue, radioactive and fluorescent dyes. However, there is little available data on outcome for ipsilateral axillary recurrence, and the sample size for most studies is small. Our study of 1, patients with 0. This study has some potential limitations. Being a retrospective study, the results may be associated with selection biases.

The adjuvant treatment details were brief and limited in our database. The quality of life measures and patient-reported outcomes were not recorded, which may be done in future studies with the same cohort of patients. It highlights the different possible methods of SLNB, and any one of them can be used as per the local resources. Minimal axillary surgery in the form of SLNB is technically feasible in low resource settings and should be offered to all eligible patients to improve quality of life with equivalent or non-inferior survival.

This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Published online May Author information Article notes Copyright and License information Disclaimer. Correspondence to: Sanjit Kumar Agrawal moc. Received Sep Keywords: breast cancer, sentinel lymph node biopsy, India. Background Breast cancer BC surgical management has changed from traditional radical surgeries to conservative surgeries with better quality of life and equivalent or non-inferior survival outcomes in the last 50 years [ 1 ].

Sentinel lymph node biopsy SLNB was performed according to the institutional protocols, with the different dye combinations as per radioactive dye availability. Outcome assessment Blue staining of the skin and necrosis at the site of MB dye injection were recorded at the time of the discharge and post-op outpatient department visit assessments.

Statistical analysis The data normalcy was checked by the Shapiro—Wilks test. Table 1. Demographic and clinical characteristics. Open in a separate window. Table 2. SLNB by different methods. Table 3. SLNB performance by years: —7 versus — Table 4. Table 5. Conflicts of interest The authors declare that they have no conflicts of interest. Funding This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. References 1.

Landmark trials affecting the surgical management of invasive breast cancer. Surg Clin North Am. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.

N Engl J Med. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B randomised phase 3 trial. Lancet Oncol. Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg. Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update.

J Clin Oncol. J Surg Oncol. J Natl Cancer Inst. Clinical practice status of sentinel lymph node biopsy for early-stage breast cancer patients in China: a multicenter study. Clin Epidemiol. Trends in axillary management of early breast cancer: a questionnaire-based pattern of practice survey for India. Indian J Surg Oncol. Sentinel lymph node biopsy mapped with methylene blue dye alone in patients with breast cancer: a systematic review and meta-analysis.

PLoS One. Diagnostic performance of indocyanine green plus methylene blue versus radioisotope plus methylene blue dye method for sentinel lymph node biopsy in node-negative early breast cancer. Haneda Airport 21 mi See all flights.

Rental Cars See all Kokubunji rental cars. Compare More Popular Hotels. View Hotel. Air conditioning. Non-smoking rooms. Hot Tub. Kokubinji is a little of the beaten path. The hotel is very well run - simple buffet breakfast, very clean well laid out rooms and on top of the train station. We enjoyed our stay and will use this hotel again The location is very convenient with easy access to the train station.

Hotel staff were very helpful and friendly. There are many restaurants within the vicinity. The room is not that big but didn't had any issues Staying at Kokubunji means living.

The outskirts of Tokyo but with less than half an hour by subway you reach the center of the metropolis. The hotel is located right in front of the station so in a very The hotel looks a little tired but it is quite ok for a short trip and just short night napping.

Using conventional key to open the room door. The hotel's lobby is located in the 3rd floor i think, see the If you are one person I think the room would be fine, but the double room for 2 was very squeeze. Pros: about m from JR station.

Many near restaurants and convince stores. Many "Luxury Bars" near by; if you into that kind of thing. Refrigerator, Microwave, and washing machine! I stayed here for 2 nights during my business visit.

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